Modern engines are typically built to tighter tolerances, and thermal expansion of parts is typically controlled better as well. So, the necessary break-in period is typically reduced, and synthetic is usually fine from pretty early on in the engine's life. And yes as stated before, several cars come w/ Mobil 1 as the factory fill, Corvette, Porsche, and 00 Cobra R, IIRC.
Personally, i run std oil for the first 2 oil changes on a new engine (1st at 1000-1500 miles, 2nd at 3500-4500 miles) then switch to Mobil 1, and recently I have been using royal purple (Thanks Mark :D)